@ARTICLE{Wróblewska2022:i6673,
	author="{Wróblewska, Agnieszka and Fajdek-Bieda, Anna and Markowska-Szczupak, Agata and Radkowska, Monika}",
	title="{Preliminary Microbiological Tests of S-Carvone and Geraniol and Selected Derivatives of These Compounds That May Be Formed in the Processes of Isomerization and Oxidation}",
	year="2022",
	type="artykuł naukowy",
	language="en",
	journal="{Molecules}",
	issn="1420-3049",
	volume="27",
	number="20",
	pages="7012(1)--7012(13)",
	doi="https://doi.org/10.3390/molecules27207012",
	url="https://www.mdpi.com/1420-3049/27/20/7012",
	keywords="natural preservatives; S-carvone; carvacrol; geraniol; nerol; linalool; citra",
	abstract="{This work presents a literature review on the biological activity of S-carvone, geraniol and
derivatives of these compounds, which are formed in the process of isomerization (during the process
of geraniol isomerization, oxidation products of this compound are also obtained). Moreover, this
work presents preliminary microbiological tests of creams with the addition of these biologically active
compounds: S-carvone, geraniol, carvacrol (an S-carvone isomerization product), nerol (a geraniol
isomerization product), linalool (a geraniol isomerization product) and citral (a geraniol oxidation
product). Because the post-reaction mixture obtained after the S-carvone isomerization has a relatively
simple composition, it was also added to creams and tested without isolating pure compounds. This
may be a cheaper alternative to creams prepared with the addition of pure compounds. The mixture
obtained after the geraniol isomerization process has a very complex composition; therefore, only
compounds with the lowest molecular weight and are easily commercially available were selected
for studies. The content of the tested compounds in the creams ranged from 0.5 to 3 wet%. The
following microorganisms were selected for microbiological tests: the Gram-negative bacterium
Escherichia coli K12, the Gram-positive bacterium Staphylococcus epidermidis, and the fungi Candida
albicans, Trichophyton rubrum, Aspergillus niger, and Penicillium chrysogenum. A content of 3% carvacrol,
nerol, geraniol and citral inhibited the growth of E. coli, and attenuated the growth of C. albicans and T.
rubrum. On the other hand, 3% carvacrol and citral only poorly attenuated the growth of the mould
fungi P. chrysogenum and A. nige}",
}