2024

Molecules

Rocznik: 2024 | Tom: 29 | Numer: 5

artykuł naukowy

angielski

EN first_page settings Order Article Reprints Open AccessArticle Evaluation of the Antimicrobial Activity of Geraniol and Selected Geraniol Transformation Products against Gram-Positive Bacteria by Anna Fajdek-Bieda 1,* [ORCID] , Joanna Pawlińska 2, Agnieszka Wróblewska 3,* [ORCID] and Agnieszka Łuś 2 1 Department of Energy and Technical Safety, Faculty of Technology, Jakub’s from Paradyż Academy in Gorzów Wielkopolski, Teatralna 25, 66-400 Gorzów Wielkopolski, Poland 2 Multispecialty Regional Hospital in Gorzow Wielkopolski, Department of Microbiology, 66-400 Gorzów Wielkopolski, Poland 3 Department of Catalytic and Sorbent Materials Engineering, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland * Authors to whom correspondence should be addressed. Molecules 2024, 29(5), 950; https://doi.org/10.3390/molecules29050950 Submission received: 10 January 2024 / Revised: 19 February 2024 / Accepted: 20 February 2024 / Published: 21 February 2024 (This article belongs to the Special Issue Antimicrobial Activity of Natural Extracts) Download keyboard_arrow_down Browse Figures Versions Notes Abstract Both geraniol and the products of its transformation, thanks to their beneficial properties, find a variety of applications in cosmetics. Due to their antioxidant and moisturizing properties, these compounds can be added to skin care products such as face creams, lotions, oils, and masks. In addition, these compounds show some antibacterial and antifungal properties, making them suitable for application in skin care products to help fight against bacteria or fungi. This study determined the antimicrobial activity of geraniol and the compounds which were formed during its transformation in relation to selected Gram-positive bacteria, and the preliminary assessment was made whether these compounds can act as ingredients of preparations with potential antimicrobial activity in the treatment of various human diseases (for example diseases of the skin, digestive system, or urinary tract). In addition, this work presents studies on the microbiological purity of cream samples obtained with different contents of geraniol and its transformation products (contents of the tested compounds: 0.5%, 1.5%, 2.5%, 4%, 8%, and 12%). Antibacterial activity tests were performed using the disc diffusion method against Gram-positive cocci, including the reference strains Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212, and against the clinical strains Staphylococcus aureus MRSA, Staphylococcus epidermidis, Enterococcus faecalis VRE VanB, Enterococcus faecium VRE VanA, and Enterococcus faecium VRE VanB. The most active ingredient against bacteria of the Staphylococcus genus was citral, followed by linalool and then geraniol. During our tests, in the case of bacteria of the Enterococcus genus, citral also showed the highest activity, but linalool, ocimenes, and geraniol showed a slightly lower activity. Moreover, this study examined the microbiological purity of cream samples obtained with various contents of geraniol and its transformation products. In the tests of the microbiological purity of cream samples, no growth of aerobic bacteria and fungi was found, which proves the lack of microbiological contamination of the obtained cosmetic preparations. On this basis, it was assessed that these compounds have preservative properties in the prepared creams. The addition of the analyzed compounds also had influence on the durability of the creams and had no effect on the change in their consistency, did not negatively affect the separation of phases during storage, and even had a positive effect on organoleptic sensations by enriching the smell of the tested samples.

2024

950(1) - 950(22)

10.3390/molecules29050950

https://www.mdpi.com/1420-3049/29/5/950

CC BY (uznanie autorstwa)

otwarte czasopismo

ostateczna wersja opublikowana

02.2024

w momencie opublikowania

140,0